2024年4月12日发(作者：)

SNX27对肿瘤细胞生物学行为的影响

及其调节的下游四基因标志物模型预

测肿瘤免疫治疗后生存结果

摘要：SNX27是一种多功能分子，在囊泡运输、膜蛋白修饰和

信号传导等过程中发挥重要作用。最近的研究表明，SNX27在

肿瘤细胞中也具有重要的作用，可以影响细胞分化、增殖、迁

移、转化和免疫逃逸等生物学行为。此外，SNX27还可以调节

多种信号通路，包括Rho GTP酶、Wnt/β-catenin、

PI3K/Akt/mTOR、NF-κB和JAK/STAT等。本文旨在探讨SNX27

对肿瘤细胞生物学行为的影响及其调节的下游四基因标志物模

型预测肿瘤免疫治疗后生存的结果。通过查阅相关文献，我们

发现SNX27的表达水平在多种恶性肿瘤中均有显著变化，且通

常呈现下调趋势。进一步实验表明，SNX27可以抑制肿瘤细胞

的增殖和迁移，并通过调节细胞周期、凋亡和自噬等机制发挥

其抗癌作用。值得注意的是，SNX27还可以调控肿瘤免疫逃逸

和免疫治疗效果。我们利用机器学习方法构建了一个包含

FOXP3、PD-L1、CTLA-4和IDO1四个标志物的模型，可以预测

肿瘤患者在免疫治疗后的生存结果。总之，SNX27是一个重要

的调节因子，可能成为治疗肿瘤的新靶点。

关键词：SNX27；恶性肿瘤；生物学行为；信号通路；免疫治

疗；预测模型

Introduction

SNX27 is a member of the sorting nexin protein family,

which plays a key role in endosomal sorting, membrane

protein modification, and signal transduction. In

recent years, emerging evidence suggests that SNX27 is

involved in the biology of cancer cells, including

differentiation, proliferation, migration,

transformation, and immune escape. Moreover, SNX27 can

regulate several signaling pathways, such as Rho

GTPase, Wnt/β-catenin, PI3K/Akt/mTOR, NF-κB, and

JAK/STAT. This review aims to discuss the impact of

SNX27 on the biological behavior of cancer cells and

its downstream genes as biomarkers for predicting the

prognosis of immune therapy.

SNX27 and Malignant Tumors

Reduced expression of SNX27 has been observed in

various types of cancers, such as breast cancer, lung

cancer, prostate cancer, and colorectal cancer.

Downregulation of SNX27 is associated with poor

prognosis and aggressive behavior of cancer cells.

Overexpression of SNX27 in cancer cells can inhibit

cell proliferation and migration, induce cell cycle

arrest and apoptosis, and activate the autophagy

pathway. SNX27 may function as a tumor suppressor by

regulating the levels of oncoproteins, such as c-Myc,

cyclin D1, and Akt.

SNX27 and Immune Escape