2024年4月12日发(作者：)

肿瘤微环境响应性金属有机配位纳米

颗粒用于肿瘤光学-化学动力学协同

治疗的研究

肿瘤微环境响应性金属有机配位纳米颗粒用于肿瘤光学/化学

动力学协同治疗的研究

摘要：现代医学中，治疗肿瘤的方法包括手术、化疗、放疗等

众多方式，然而这些治疗方式都会对患者产生不良反应，且难

以完全根治肿瘤。因此，寻求新的肿瘤治疗方式是很有必要的。

近年来，纳米技术的发展为肿瘤治疗提供了新的思路。在这一

领域，金属有机配位纳米颗粒被认为是一种有很大潜力的技术，

可以用于肿瘤光学/化学动力学协同治疗。本论文将综述金属

有机配位纳米颗粒的特性、肿瘤微环境响应机制及其在肿瘤治

疗中的应用。通过文献综述及对该领域的分析，我们得出以下

结论：金属有机配位纳米颗粒具有可调节性、组装性和多功能

性等优良性质，能够响应肿瘤微环境中特定的生物学和物理化

学条件，并释放相应的药物、光学或热能量，从而实现针对性

的肿瘤治疗。该领域还存在一些需进一步研究解决的问题，如

配位纳米颗粒的生物安全性、可操作性等，这需要更深入的实

验和理论研究。

关键词：金属有机配位纳米颗粒，肿瘤微环境，响应性治疗，

光学治疗，化学动力学治

Introduction

Cancer is a major public health issue worldwide, and

it has become a pressing challenge to develop

effective and safe treatments. Current treatment

strategies, including surgery, chemotherapy, and

radiation therapy, have shown limited success and can

cause adverse effects. Therefore, there is a need to

explore new therapeutic approaches. In recent years,

nanotechnology has emerged as a promising tool for

cancer treatment. Among nanomaterials, metal-organic

coordination nanoparticles (MOCNPs) have attracted

significant attention due to their unique properties,

which enable them to respond to tumor

microenvironments and release therapeutic agents or

energy selectively.

Properties of MOCNPs

MOCNPs are composed of metal ions and organic ligands,

forming complex structures with tunable sizes, shapes,

and surface properties. These particles possess a high

degree of stability and biocompatibility and can be

readily synthesized through simple and versatile

methods. Furthermore, MOCNPs can be easily modified by

attaching targeting ligands or therapeutic agents to

their surfaces, enabling them to selectively