2023年7月18日发(作者：)

系统医学2018年1月第3卷第2期DOI院10.19368/.2096-1782.2018.02.063窑内科研究窑IFABP及D-乳酸对急性肠梗阻患者病情严重程度及预后的指导价值霍玲玲1袁孙昭睿21.南京中医药大学连云港附属医院消化内科袁江苏南京222000曰2.南京中医药大学连云港附属医院重症医学科袁江苏南京222000[摘要]目的探讨肠脂肪酸结合蛋白渊IFABP冤及D-乳酸对急性肠梗阻患者的病情严重程度及预后的指导价值袁为急性肠梗阻尤其是绞窄性肠梗阻的早期诊治提供血液学检查特异性指标及实验依据遥方法选择2016年7月要2017年6月该院急性肠梗阻患者60例为观察组袁并纳入同期健康体检者60名为对照组袁检测并比较两组受试者血液中IFABP及D-乳酸水平袁并观察IFABP及D-乳酸水平与观察组患者疾病严重程度及预后的关系遥结果观察组入院1hIFABP为渊982.34依86.77冤ng/mL尧D-乳酸水平为渊326.19依110.85冤滋g/L袁明显高于对照组的组中绞窄性肠梗阻患者血清IFABP为渊1538.02依142.13冤ng/mL袁D-乳酸水平为渊415.31依130.97冤滋g/L袁均显著高于0.05冤曰入院6h后袁经治疗观察组单纯性肠梗阻及绞窄性刚梗阻患者血清IFABP为渊212.06依68.83冤ng/mL及单纯性肠梗阻患者的渊736.12依72.68冤ng/mL尧渊283.52依102.92冤滋g/L袁差异有统计学意义渊tIFABP=27.51袁tD-乳酸=4.33袁P<渊160.76依75.82冤ng/mL尧渊218.46依65.17冤滋g/L袁差异有统计学意义渊t1hIFABP=55.23袁t1hD-乳酸=6.49袁P<0.05冤曰入院时袁观察渊210.98依70.21冤ng/mL袁D-乳酸分别为渊234.61依64.05冤滋g/L尧渊235.86依64.57冤滋g/L袁均较入院1h时降低袁差异有统计学意义渊t6hIFABP=0.06袁t6hD-乳酸=0.07袁P>0.05冤曰血清IFABP及D-乳酸用于诊断急性肠梗阻患者粘膜损伤的AUC分别为中参考价值较高袁且对患者预后具有较高的临床指导价值遥[中图分类号]R574[文献标识码]A学意义渊t单IFABP=28.67袁t单D-乳酸=2.21袁t绞IFABP=45.85袁t绞D-乳酸=6.73袁P<0.05冤袁但观察组两种疾病类型之间差异无统计0.808和0.875袁最佳临界值分别为843.96ng/mL和335.37滋g/L遥结论血清IFABP及D-乳酸在急性肠梗阻的诊断[关键词]肠脂肪酸结合蛋白曰D-乳酸曰急性肠梗阻曰诊断曰预后[文章编号]2096-1782渊圆园员8冤01渊b冤原园063-04ValueofIFABPandD-LactateinGuidingtheSeverityofDiseasesandPrognosisofPatientswithAcuteIleusHUOLing-ling1,iveSystemDepartment,LianyungangAffiliatedHospitalofNanjingUniversityofChineseMedicine,Nanjing,Nanjing,JiangsuProvince,222000ChinaJiangsuProvince,222000China曰,LianyungangAffiliatedHospitalofNanjingUniversityofChineseMedicine,[Abstract]ObjectiveTostudythevalueofIFABPandD-Lactateinguidingtheseverityofdiseasesandprognosisofpatientswithacuteileusthusprovidingthehematologicalexaminationspecificityindicatorsfortheearlydiagnosisandtreas60casesofpatientswithacuteileusinourhospitalfromJuly2016toJune2017wereselectedastheobservationgroup,60casesofhealthyphysicalexam鄄inationpeopleatthesameperiodwereselectedasthecontrolgroup,andthelevelsofIFABPandD-Lactateweretest鄄sTheIFABPandD-Lactatelevelsat1hafteradmissionintheobservationgroupwereobvi鄄[作者简介]霍玲玲渊1984-冤袁女袁江苏连云港人袁本科袁主治医师袁主要从事消化内科常见疾病诊治工作遥[通讯作者]孙昭睿渊1982-冤袁男袁江苏连云港人袁本科袁主治医师袁主要从事重症医学方面的研究袁E-mail:sunzhaorui2010@遥SYSTEMSMEDICINE系统医学edandthecorrelationbetweentheIFABPandD-Lactateandseverityofdiseasesandprognosisofpatientswithacute63