2024年4月11日发(作者：)

光诱导下fe催化下脱羧氟烷基氢化修饰新方法

As an emerging field in organic chemistry, the catalytic

transformations of fluorinated compounds have attracted significant

attention in recent years (作为有机化学中的新兴领域，氟化合物的催化

转化在近年来引起了广泛的关注). The utilization of light as a driving

force in chemical reactions, known as photoredox catalysis, has

brought about revolutionary changes in synthetic chemistry (利用光

作为化学反应的驱动力，即光氧化还原催化，已经在合成化学领域带来了革

命性的变化). Integrating these two areas, a new method for the

decarboxylative fluoromethylation of alkyl carboxylic acids under the

influence of light-activated iron catalysis has been developed

recently (在这两个领域的基础上，最近发展了一种光催化铁催化剂促进的

脱羧氟甲基化反应的新方法).

The use of light as the driving force offers several advantages, such

as milder reaction conditions, improved selectivity, and the potential

for environmentally-friendly processes (利用光作为驱动力有几个优点，

比如更温和的反应条件，提高了选择性，并且有潜力实现环保的过程). This

new method can generate valuable fluorinated compounds from

readily available starting materials, making it a highly attractive

strategy in organic synthesis (这种新方法可以从易获得的起始原料中生成

有价值的氟化合物，使其成为有机合成中非常吸引人的策略). The ability to

functionalize alkyl carboxylic acids under mild conditions opens up

new possibilities for accessing diverse fluorinated molecules with

potential applications in pharmaceuticals, materials science, and

agrochemicals (在温和条件下对烷基羧酸进行官能化的能力为访问具有潜

在药物、材料科学和农药应用的多样化氟化分子开辟了新的可能性).

One of the key challenges in developing this new method lies in the

design and optimization of the light-activated iron catalyst (开发这种

新方法的一个关键挑战在于设计和优化光活化的铁催化剂). The catalyst

should be able to effectively harness light energy to initiate the

desired transformation while maintaining good stability and

reactivity under the reaction conditions (催化剂应能够有效地利用光能

来启动所需的转化，同时在反应条件下保持良好的稳定性和反应性).

Additionally, the selectivity of the catalytic process must be carefully

controlled to ensure the formation of the desired fluorinated

products with high efficiency (此外，必须仔细控制催化过程的选择性，

以确保以高效率形成所需的氟化产物).

Another aspect that requires intensive investigation is the scope and

limitations of the new method in terms of substrate compatibility

and functional group tolerance (需要深入研究的另一方面是新方法在底

物兼容性和官能团耐受性方面的范围和局限性). While the initial studies

have shown promising results with certain alkyl carboxylic acids, it is

important to explore the generality of this method across a wide

range of substrates with varying structural and electronic properties

(尽管最初的研究在某些烷基羧酸上显示出了令人鼓舞的结果，但重要的是

要探索这种方法在各种具有不同结构和电子性质的底物上的广泛适用性).

Understanding the factors that influence the reactivity and selectivity

of the reaction will be crucial for further advancing the application of

this method in the synthesis of complex fluorinated molecules (了解

影响反应反应性和选择性的因素将对进一步推进这种方法在合成复杂氟化分

子中的应用至关重要).

In addition to the technical aspects, the practical considerations of

implementing this new method in the laboratory and industrial

settings should be taken into account (除了技术方面，还应考虑在实验

室和工业环境中实施这种新方法的实际考虑). This may include the

availability and cost-effectiveness of the starting materials, the

scalability of the reaction conditions, and the potential for

integrating the method into existing synthetic processes (这可能包括

起始原材料的可用性和成本效益、反应条件的可伸缩性以及将该方法整合到

现有合成过程中的潜力). Addressing these practical considerations will

be essential for realizing the full potential of this new method in the

synthesis of fluorinated compounds on a larger scale (解决这些实际考

虑将对在较大规模上实现这种新方法在合成氟化合物方面的全部潜力至关重

要).